Detecting Susceptibility Genes for Late-onset Alzheimer's disease


Study ID: 3808
Short Title: AD GENETICS
Organisation: Isle of Wight NHS Trust
Location: Isle of Wight NHS Trust
Condition: Alzheimer's Disease
Main Specialty: Dementias
Expected End Date: 01/02/2020
Postcode: PO30 5TG
Contact Name: IOW Research Team
Contact Email: research@iow.nhs.uk
Active: Yes

Inclusion Criteria

Early Onset AD inclusion criteria:


Less than or equal to age 64 at onset (can be of any age at study entry) Meets ADRDA/NINCDS criteria for diagnosis of probable AD Willingness to provide a blood sample Caucasian

Exclusion Criteria

Early onset AD exclusion criteria:


Current major depressive episode, psychosis (not associated with AD), acute manic or depressive episode of bipolar disorder Current diagnosis of substance abuse or substance dependence

Study summary:

Our current programme of research is focused on identifying rare genetic variants of moderate to strong effect observed in the coding regions of genes.We aim to compare 300,000 DNA variants from throughout the human genome, in 20,000 AD cases and 49,000 controls. Through sample collection and collaboration we will enrich our clinical samples to include 1000 individuals with early onset AD. This group are more likely to have rare genetic changes of moderate to large effect on their development of disease.


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