Inclusion criteria, exclusion criteria and study summary
An increasing number of patients with early rectal cancer in the UK are being identified through the bowel screening programme. There is a growing number of patients who may not be suitable for surgery, due to other medical comorbidities and factors. These patients may suffer from symptoms as their cancer grows, including pain, diarrhoea and the need for a stoma (bowel bag). For these patients, radiotherapy combined with chemotherapy, or radiotherapy only is used. A standard dose of radiotherapy given over 5.5 weeks can lead to the cancer disappearing in about one third of patients. In this trial we want to find out if a higher radiotherapy dose given over the same time will give greater benefit to patients with acceptable side effects. This could lead to better treatment and improved quality of life.