MOSAICC: an in-depth case-control study of Myeloproliferative Neoplasms

Study ID: 45162
Short Title: MOSAICC STUDY
Trust Name: UHD,UHS
Recruitment Site: Royal Bournemouth Hospital,Southampton General Hospital
Disease Area: Upper GI
Phase: N/A
Expected End Date: 31/12/2024
Postcode: SO16 6YD
BH15 2JB
Contact Name: Amanda Pattie
Contact Email: studysupport1and3.crnwessex@nihr.ac.uk
Active: Yes

Inclusion criteria, exclusion criteria and study summary

• Have clinically confirmed MPN diagnosis (PV, ET or PMF); see definitions above. • Have been informed that they have a MPN. • Diagnosed within the previous 24 months. • Aged 18 years and over. • Capable of giving informed consent as determined by the treating clinician. • Physically and cognitively capable of completing the questionnaire as determined by the treating clinician. • Capable of completing the questionnaire in English language as determined by the treating clinician.

• Patients under 18 years old. • Where the clinician does not agree to inclusion • Incapable of giving informed consent as determined by the treating clinician. • Physically or cognitively incapable of completing the questionnaire as determined by the treating clinician. • Incapable of completing the questionnaire in English language as determined by the treating clinician. • Too ill to participate. The WHO performance evaluation scale will be used at the stage of participant identification by the clinician and retained. Only those scoring 0-3 will be considered eligible for inclusion in the study. Those scoring 3 are described as “Symptomatic > 50% in bed but not bedbound”. • Patients not expected to live more than 2 months. • Those who do not speak English language.

There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The research group will conduct a UK wide case-control study of 560 patients with classic MPNs and up to 560 non-blood relative or friend controls to investigate the causes (aetiology) of MPNs and to evaluate quality of life2 (QoL). DNA and RNA samples from MPN patients and controls who participate in the case-control study will be collected and retained to evaluate gene-environment interactions upon receipt of additional funding.

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