Assessment of novel biomarkers in head and traumatic brain injury

Study ID: 10059
Short Title: Novel biomarkers of brain injury
Organisation: University Hospital Southampton NHS Foundation Trust
Location: Southampton General Hospital
Condition: Other TBI Traumatic Brain Injury
Main Specialty: Neurological disorders
Expected End Date: 01/02/2019
Postcode: SO16 6YD
Contact Name: UHS R&D Office
Contact Email: R&
Active: Yes

Inclusion Criteria

Study group Patients who have suffered a severe head injury (assessed on Glasgow Coma Scale as being  8) being managed within the first 72hours of injury on the NeuroIntensive Care Unit at Wessex Neurological Centre. Patients will need to have insertion of an ExternalVentricular Drain as part of their normal intensive care management to allow sampling of CSF. Control patients – Patients for excision of pituitary tumour who are having a lumbar drain placed at the time of surgery.

Exclusion Criteria

For those with severe head injury, there should be no evidence of other major traumatic injury (i.e. long bone fracture, internal haemorrhage). Those not expected to survive twenty fours hours will be excluded. For controls sample those with recent head injury or known neurological disease.

Study summary:

Head Injury and traumatic brain injury (TBI) are a major cause of morbidity and mortality worldwide. There is preliminary evidence based on animal studies that TBI is associated with elevation of markers of neuronal damage in CSF (cerebro¬spinal fluid) and blood serum. One example of this is S100B, however a complicating factor is this is not specific to neuronal damage. There is preliminary evidence from animal studies (unpublished) that breakdown products of neuronal cytoarchitecture e.g. Alpha¬II¬spectrin can become elevated after brain injury. An assay for this has been developed and the aim for this study is to determine whether in patients with acute brain injury is associated with elevated levels of these novel, specific biomarkers. Initial studies will focus on a comparison of patients with severe brain injury compared to those without (control). The study will look at both CSF and blood levels of the markers. It will involve taking a single sample of both blood and CSF at a time point were it would normally be taken as part of the patients routine care. The volume blood needed for the assay will be small

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