For blood samples: anaemia (haemoglobin < 11g/dl) significant bleeding tendency
Multiple sclerosis is the commonest cause of irreversible neurological disability in the young adults. There is no treatment for progressive disability which occurs as a result of neuronal loss during inflammation. There is preclinical evidence to suggest that systemic inflammation, such as during a peripheral infection (eg respiratory or bladder infections), may exacerbate inflammation in the brain and contribute to disability progression. We plan to find out whether this is truly the case in persons with multiple sclerosis. Patients with multiple sclerosis will be followed up for a period of up to 5 years, whilst recording disability progression and inflammatory events such as infections, surgery or vaccinations.
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