Inflammation and disability progression in multiple sclerosis

Study ID: 17661
Short Title: Inflammation and disability progression in multiple sclerosis
Organisation: University Hospital Southampton NHS Foundation Trust
Location: Southampton General Hospital
Condition: Multiple sclerosis
Main Specialty: Neurological disorders
Expected End Date: 30/09/2020
Postcode: SO16 6YD
Contact Name: R&D department
Contact Email: R&
Active: Yes

Inclusion Criteria

Multiple sclerosis

Exclusion Criteria

For blood samples: anaemia (haemoglobin < 11g/dl) significant bleeding tendency

Study summary:

Multiple sclerosis is the commonest cause of irreversible neurological disability in the young adults. There is no treatment for progressive disability which occurs as a result of neuronal loss during inflammation. There is preclinical evidence to suggest that systemic inflammation, such as during a peripheral infection (eg respiratory or bladder infections), may exacerbate inflammation in the brain and contribute to disability progression. We plan to find out whether this is truly the case in persons with multiple sclerosis. Patients with multiple sclerosis will be followed up for a period of up to 5 years, whilst recording disability progression and inflammatory events such as infections, surgery or vaccinations.

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