Parkinson's Families Project (PFP)

Study ID: 18437
Short Title: Parkinson's Families Project (PFP)
Organisation: Poole Hospital NHS Foundation Trust
Location: Poole General Hospital
Condition: Parkinson's disease
Main Specialty: Neurological disorders
Expected End Date: 01/03/2027
Postcode: BH15 2JB
Contact Name: R&D department
Contact Email: R&
Active: Yes

Inclusion Criteria

•Age over 15 years. •Either (1) Affected by Parkinson’s disease / Parkinsonism (PD) and either age at onset < 45 years, or at least one first or second degree family member affected by PD (father, mother, sister, brother, child, grandparent, uncle aunt) Or (2) Relative of (1) affected or unaffected by PD

Exclusion Criteria

Lack of capacity to consent to participate in project.

Study summary:

One person in every 500 has Parkinson’s and around 127,000 people are living with the condition in the UK. The aim of the study is to identify new genes that predispose or cause Parkinson's Disease or Parkinsonism. There is a pressing need to study the genetic makeup of family members both with and without Parkinson's. As families share a common genetic background, it is easier to find new Parkinson's genes by studying the genetic makeup of people with Parkinson's alongside other members of their families. We are particularly interested in studying the genetic makeup of two groups of people: 1) those who developed Parkinson's before the age of 45; and 2) those who have a family history of other relatives affected by Parkinson's. By identifying genetic factors that cause Parkinson's, we hope to understand more about the condition. Doing so will lead to the development of better diagnosis, improved disease models, and we hope in time, to the development of better treatment.

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