The impact of upper-body high-intensity interval training on postprandial metabolic control in persons with chronic paraplegia

Study ID: 40870
Short Title: Upper-body interval training in persons with chronic paraplegia
Organisation: Salisbury NHS Foundation Trust
Location: Salisbury District Hospital
Condition: Other
Main Specialty: Neurological disorders
Expected End Date: 31/12/2019
Postcode: SP2 8BJ
Contact Name: R&D department
Contact Email:
Active: Yes

Inclusion Criteria

1. Male of female 2. Aged between 18 and 65 years 3. Individuals with a chronic SCI (> 12 months post-injury) below the sixth thoracic (T6), with a motor complete injury or incomplete injury (providing > 75% waking day is spent wheelchair-bound). 4. Physical activity level (PAL) < 1.6 (i.e. sedentary) 5. Weight stable (weight not changed by > 3% in the last 3 months)

Exclusion Criteria

1. Individuals with an acute (< 12 months post injury) SCI 2. Individuals self-reporting active medical issues including pressure sores, urinary tract infections, cardiac disorders, cardiovascular contraindications for testing or musculoskeletal complaints of the upper extremities. 3. Individuals on type 2 diabetes medication. 4. Individuals self-reporting use of lipid-lowering agents or anti-hyperglycaemics 5. Individuals self-reporting use of anti-inflammatory vitamins or anti-oxidant vitamins 6. Plans to change lifestyle (e.g. diet or physical activity level) during the study period

Study summary:

Individuals with a spinal cord individual (SCI) have a higher mortality rate than non-disabled populations, largely explained by a higher prevalence of chronic diseases (e.g. cardiometabolic syndrome). High-intensity interval training (HIIT) is a mode of exercise that may be an effective solution to improving cardiometabolic health and the prevalence of chronic disease, but has yet to be investigated in persons with chronic paraplegia (paralysis of the lower extremities, > 12 months post-injury). To investigate the potential of an acute HIIT bout at improving postprandial metabolism, this study will recruit 11 physically inactive adults with chronic paraplegia (SCI below T6). The study will involve a total of 4 visits to the laboratory (1 x ~2.5 hours; 3 x 8 hours). For all visits, we will ask participants to arrive following an overnight fast (> 10 hours). In visit 1, we will assess body composition (height, weight, waist circumference, and hip circumference), resting metabolic rate (RMR), and peak aerobic capacity, in addition to performing a shortened HIIT familiarisation session. Participants will be sent away with a physical activity monitor to wear for 1 week, and asked to return to check eligibility for visits 2-4. Eligible participants will then complete 3 trials in a randomised-cross over design; performing either; HIIT or moderate-intensity continuous exercise MICT on an arm-crank ergometer, or a resting control condition. A cannula will be inserted into a vein in the forearm and participants will be fed a mixed-macronutrient meal. Regular blood samples will be taken for the following 6 h whilst participant’s rest in bed.

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